Sentence examples for substitution of multiple from inspiring English sources

Substitution of multiple AAs led to an abrogation of binding in the remaining peptides.

Then there are changes that hit Sundays harder, like the substitution of multiple three-day weekends for the old two- or three-week vacation, so people are not around on Sundays to buy the paper.

Although various oligonucleotide backbone modifications have been invented for more efficient binding to complementary RNA [23, 24], these modifications require substitution of multiple nucleotides.

The evolution of high levels of resistance to an antibiotic via mutation sometimes involves the substitution of multiple mutations.

Epistasis, the non-additive interaction of mutations at multiple loci, plays a major role when resistance to antibiotics requires the sequential substitution of multiple mutations.

In the model, substitution of multiple phenylalanine residues by serine [ 11] led to a predicted increase of the ratio of turn-forming residues in the formula and thus to a lowered predicted solubility in E. coli.

We did not proceed further with these experiments because substitutions of multiple internal domains also decreased cell-surface expression of the receptors (data not shown).

This semantics extends the familiar economic notion of marginal rate of substitution to multiple continuous or discrete attributes.

The number of polymorphic sites is lower than the sum of synonymous and non-synonymous substitutions because of multiple different bases in some polymorphic sites.

Thus, the TEs present in a genome today have different ages, and the substitution patterns they generate are indicative of multiple substitution processes taking place over long periods of time, perhaps even prior to insertion into their present locations.

Indeed, it is expected that the estimated substitution rates will be an average of multiple substitution rates that reflect the proportion of each viral subtype in the data set analysed.