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We show the OR43b gene on the balancer chromosome SM5 is expressed at reduced levels and contains nucleotide polymorphisms predicted to alter two amino acids in the receptor, including an arginine128 to proline substitution in the first extracellular loop.
We also tested two TatC variants: TatC P48A) carries a substitution in the first periplasmic loop region that abolishes export and partially impairs TatC interaction with TatB [49] and TatC(E103R) has a substitution in the first cytoplasmic loop between predicted transmembrane helices II and III that blocks export but does not affect TatBC complex formation [54].
Regardless of DNA source (GBM patients or control subjects), A*3201 had six unique SNPs (Figure 1b), one of which (rs2230954) is nonsynonymous (Ser to Leu substitution) in the first exon.
Some of them were not aware of the substitution in the first place and/or felt strongly against it.
Erythrocyte and thrombocyte counts as well as Hb values were lowest at ECC onset, normalizing under substitution in the first 4 hours after surgery.
Previous studies demonstrated that CDS has a T → G substitution in region IV and a D → N substitution in the first aspartate in region V [ 1, 2].
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Howe has explained that he has not used a defensive substitution in the ninth inning for Cedeño because he wants to show faith in him, and Cedeño desperately needs self-confidence to succeed.
A trochaic substitution is quite normal in the first foot of an iambic pentameter line; a trochaic substitution in the second foot, however, creates a marked disturbance in the rhythm.
For HEK293 site 4, the expected substitution in the sixteenth base distal from the PAM was observed in all samples (Fig. S3A), although the wild type genotype was also detectable in a few samples (Fig. S3B).
SLR1 encodes IAA14, a member of the auxin indole acetic acid (Aux/IAA) protein family; the mutation corresponds to a single amino acid substitution in the second of four highly conserved domains.
A C-to-A substitution in the second exon of the GS3 gene is strongly associated with grain length and width: the A-allele confers significantly longer and thinner grains than the C-allele (Takano-Kai et al. [2009]; Fan et al. [2006]).
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