On one hand, antithrombin research conducted during the past two decades has attempted to establish the effectiveness and safety of antithrombin substitution in cases of severe sepsis in accordance with the criteria of evidence-based medicine.
For simplification, we considered only one substitution randomly in case of three substitutions per codon and did not consider multiple substitutions at the same site.
linC, which encodes for HCH dehydrogenase was most conserved among the genes of the upper degradation pathway and demonstrated only a single substitution: Y172C in case of IP26.
Process indicators (existence of patient will/advance directive, substitution arrangement in case of unavailability of the treating general practitioner, cooperation with nursing services) are assessed at the beginning of the observation period and at the end if changes occur.
The technique for selective resurfacing was chosen for treating the patella [7]: patellar substitution only in cases of severe cartilage damage, serious deformity and wrong- racking; patellar conservation in the remaining cases.
In addition, we also observe binding specificity linked to the sulfate substitution positions in cases of equal sulfation degree.
Referring to the kind of digestate, the following credits were determined: substitution of mineral fertilizer (nitrogen, phosphorus, potassium), substitution of peat (only in case of finished compost), humus accumulation (carbon-sink), and humus reproduction (i.e., for maintaining soil fertility).
In autoimmune thyroiditis presenting with mood disorders (Table 3), thyroid hormone substitution has been used in case of hypothyroidism (Schmidt et al. 1990; Mahmud et al. 2003; Stowell and Barnhill 2005; Tor et al. 2007; Liu et al. 2011; Lin et al. 2013) or antithyroid drugs in case of hyperthyroidism (Bokhari et al. 1998; Müssig et al. 2005).
Similarly, although the N143S substitution has a retardation effect on nucleation, the retardation effect was neutralized by the presence of the V112M substitution in the case of huPrP.
The 1H NMR spectrum exhibited meta coupled doublets (J = 3.0 Hz) at δ 6.58 and 6.44 showing matching substitution in A ring as in case of compound 1.
In case of substitution with a chiral branched alkyl chain, 5a, strong signals have been recorded by means of circular dichroism spectroscopy.
