Sentence examples for substitution grades from inspiring English sources

Thus, for the missense substitutions that were observed in our mutation-screening study and subjected to functional assays, there is a qualitative trend toward agreement between the Align-GVGD classification and the functional assay result, consistent with the trend in ORs that we observed across the Align-GVGD-defined ordered series of missense substitution grades.

The batches had the same substitution grade and viscosity but behaved differently with respect to their capacity for gelation and polymer release and it was concluded that these differences were correlated to the substitution pattern of the HPMC batches.

Studies report pruritus occurrence in none to 55% of patients [ 5- 12] and it is controversial if HES 130/0.38 to 0.45 causes less pruritus than the HES solutions with higher molecular weight and substitution grade [ 10].

It may even mean the substitution of lower grade ingredients.

Rather than generating a binary classification, Align-GVGD categorizes missense substitutions into seven grades ordered from evolutionarily most likely (C0) to least likely (C65) [ 45].

There was less of a decrease in carbonate substitution between increasing DCIS grades and DCIS HG and IDC G1 were similar in their carbonate content, suggesting the calcification in high-grade DCIS is in a chemical state similar to that found within early invasive disease.

Bone density in hypogonadal men of all ages increases under testosterone substitution (8, 11, 48) (Level 1b, Grade A).

These processes must be suitably developed and tested for the production of medical grade substitutions.

In patients who required platelet substitution to maintain a CTCAE Grade <4 before treatment, a CTCAE Grade 4 thrombocytopenia after treatment did not constitute a dose-limiting toxicity.

Thus the statistical evidence in favor of pathogenicity from the trend test was stronger than that generated by either the binary test over all the missense substitutions or the test for any individual grade of missense substitution.

Four patients were excluded from further D/F treatment, three because of thrombocytopenia NCI-CTC grade 3 (after the second, fourth and sixth cycle, respectively) and the other patient because of thrombo-cytopenia of NCI-CTC grade 4 (after the eigth cycle of D/F), which was accompanied by anaemia NCI-CTC grade 3, necessitating substitution of platelets and two units of packed red cells.