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Exact(2)
The batches had the same substitution grade and viscosity but behaved differently with respect to their capacity for gelation and polymer release and it was concluded that these differences were correlated to the substitution pattern of the HPMC batches.
Studies report pruritus occurrence in none to 55% of patients [ 5- 12] and it is controversial if HES 130/0.38 to 0.45 causes less pruritus than the HES solutions with higher molecular weight and substitution grade [ 10].
Similar(58)
Thus, for the missense substitutions that were observed in our mutation-screening study and subjected to functional assays, there is a qualitative trend toward agreement between the Align-GVGD classification and the functional assay result, consistent with the trend in ORs that we observed across the Align-GVGD-defined ordered series of missense substitution grades.
It may even mean the substitution of lower grade ingredients.
These processes must be suitably developed and tested for the production of medical grade substitutions.
Thus the statistical evidence in favor of pathogenicity from the trend test was stronger than that generated by either the binary test over all the missense substitutions or the test for any individual grade of missense substitution.
Bone density in hypogonadal men of all ages increases under testosterone substitution (8, 11, 48) (Level 1b, Grade A).
In patients who required platelet substitution to maintain a CTCAE Grade <4 before treatment, a CTCAE Grade 4 thrombocytopenia after treatment did not constitute a dose-limiting toxicity.
The more severe grades were assigned sequentially higher severities, with C65 substitutions assigned a severity grade of 6 (Tables 4 and 6).
Our analysis thus conformed to the conditions under which Align-GVGD was calibrated and was used to grade missense substitutions in ATM [ 7, 45].
There was less of a decrease in carbonate substitution between increasing DCIS grades and DCIS HG and IDC G1 were similar in their carbonate content, suggesting the calcification in high-grade DCIS is in a chemical state similar to that found within early invasive disease.
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