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The approximate increase in NSAID expenditure that arose due to increased NSAID prescription volume was estimated by deducting the previous (substitution) estimate of what the total expenditure on the five NSAIDs would have been in the final quarter (based on a constant nsaid volume) from the actual total expenditure on the five NSAIDs (in the final quarter).
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Some critics of S-chip like to cite substitution estimates that are much higher.
For instance, Solow (1987) demonstrates convincingly that compositional changes in output can lead to incorrect substitution estimates in studies using aggregate data.
The mean rate of nucleotide substitution estimated from dated IHHNV capsid sequences under assumptions of both strict and relaxed molecular clocks were comparable and unexpectedly high for a DNA virus such as IHHNV.
For distance and likelihood-based trees we used a model of nucleotide substitution estimated in Modeltest 3.6 [ 26].
Additionally, we constructed Bayesian trees in MrBayes 3.2 [ 27] using a model of nucleotide substitution estimated in MrModeltest 2.2 [ 28].
The mean rate of nucleotide substitution estimated for the N gene was 2.2 × 10 substitutions/site/year (95% highest posterior density [HPD] values 1.3 3.2 × 10 substitutions/site/year).
The ratio of the 1,4- to the 1,5- substitution estimated by integrating the area of each triazole C H peak was 2 : 1.
BI was implemented with the program Mr.Bayes v3.1.2 [ 59] under a partitioned model (dataset divided into genes), and considering the model of nucleotide substitution estimated with jModelTest.
The mean rate of nucleotide substitution estimated for the N gene was 2.3 × 10 substitutions/site/year (95% highest posterior density [HPD] 1.4 3.1 × 10 substitutions/site/year).
To compare patterns of substitution across the mitochondrial genome for select branches or groups of branches, we first divided substitution estimates for each window by the median substitution rate across all windows.
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