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Stimuli for the individual condition were created by substituting agent A's communicative action with a non-communicative action with the same onset and duration ('Turn', 'Jump', 'Sneeze', 'Lateral step', 'Drink'Drink
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Such stabilised 'triazene' derivatives address the potentially compromised pharmaceutical profile of TAB and the 3′-amine substituted agents afford conformationally flexible substitutes.
A main substitute agent is the analogue carboplatin [ 4, 5] but also other combined agents including taxanes (paclitaxel, docetaxel) or gemcitabine, vinorelbine, pemetrexed and irinotecan have been used [ 6– 14].
Therefore, these agents cannot be quickly substituted for agents associated with hypoglycemia during periods of fasting (31).
Precise knowledge of equilibria under oxygen-free conditions would enable evaluation of the reversible oxygen uptake in the same Co II)–amino acid imidazole systems, which are known models of artificial blood-substituting agents.
Therefore, blocking the final process in hydrogen ion secretion reduces acid secretion and this is the mechanism of action of the substituted benzimidazole agents known as proton pump inhibitors (PPI).
However, substituting an ultrasound contrast agent resulted in an increase in diagnostic accuracy from 77 % to 85%[13]3] by allowing clear delineation of the uterine cavity and free flow of contrast along the Fallopian tubes and peritoneal spill.
Our objective is to increase the efficacy of the CA-4 as an anti-tubulin and antimitotic agent by substituting the cis-alkene bond with one of its bioisosteres, the 1,2,4-oxadiazole ring.
In this regard, nanobodies that are radio-iodinated with I could serve for PET imaging and dosimetry purposes, whereas I could be applied in TRNT, without substituting the actual theranostic agent.
Clinical studies in patients with RA have shown that adding or substituting an anti-TNF agent to the existing methotrexate therapy 3 4 7 19 20 results in a significant improvement in the therapeutic response.
135 Etomidate is a substituted imidazole anesthetic agent that inhibits 11β-hydroxylase.
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