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This paper presents the reconstruction of surface epithelia for the treatment of pathological conditions of skin and cornea and the development of 3D tissue-engineered substitutes based on a collagen GAG chitosan matrix for the regeneration of skin and cornea.
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In this study we were able to generate a three-layered skin substitute based on a fibrin hydrogel.
In this study we were able to generate for the first time a three-layered skin substitute based on a fibrin hydrogel.
For the first time we were able to generate a three-layered skin substitute based on a fibrin hydrogel not only serving as a dermal and epidermal substitute but also including the hypodermis.
Several Silicon Valley scientists are producing edibles of the truly bizarre inside their labs or mixing up animal substitutes based on some interesting ingredients.
This study investigated the effect of six lab-produced saliva substitutes based on carboxymethylcellulose (CMC) differing in octacalciumphosphate saturations (OCP-s) on mineralisation of bovine dentin in vitro.
Dokmak et al. summarized the features of these substitutes based on six characteristics: availability, difficulty of harvesting, necessity of additional incision, risk of infection, need for long-term anticoagulation, and cost [8].
Although recently introduced substitutes based on 0.55% ortho-phthaldehyde (OPA), 7% to 14% hydrogen peroxide, and 0.1% to 0.3% peracids are considered less toxic than glutaraldehyde, OPA can be a potential respiratory sensitizer, and the materials compatibility profile of peroxide/peracids at effective concentrations remains an issue.
Green chemistry proceeds application by application, looking for potential substitutes based on desired functions.
Advances in biomedical science have allowed the development of engineered skin tissue substitutes based on data published more than 30 years ago [ 60- 62].
The types of cartilage ranged from artificial, cell-free matrix substitutes based on collagen/peptide matrices [ 9] or extracted cartilage components (reconstituted from milled cartilage) [ 10] to in vitro generated, cell-containing matrices (derived from the three-dimensional (3D) culture of chondrocytes) [ 11].
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