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We found that community participation has substituted the role of the central and local governments, and that the collaboration between the council and other stakeholders has provided a way for El Triunfo to satisfy some of its demand for water.
In the context of the present discussion, an intriguing explanation could be formulated as: group I introns might have existed in proto-tRNAs, and proteins (peptides) aiding their self-splicing emerged later, which finally evolved into AARSs, and substituted the role of the introns in favoring the synthesis of aminoacyl-tRNAs.
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The government should not substitute the role of the existing society.
Notwithstanding, several faith-based humanitarian organizations substitute the role of the state in education until the state establishes mechanisms for the integration of Syrian children into national education system.
Arora et al. discussed the role of the glucocorticoid receptor (GR) in substituting the role of the AR after AR inhibition.
The Arg215 side chain coordinates the β-phosphate group of ATP and together with His200 they partially substitute the role of Mg2+ ions.
Acting through adaptors, C-DRTs could transform into much shorter templates (called "proto-mRNAs" here) and substitute the role of DRTs, thus significantly saving the replication cost.
NrdB proteins with a MnIV-FeIII metal centre substituting the role of the tyrosyl radical [ 7, 8] are denoted NrdBPhe or NrdBLeu.
Therefore, what the approaching of the accept stem and the anticodon loop described in Figure 4 implies is actually that the operational code might have occurred when the proteins (peptides) aiding the group I intron's self-splicing began to substitute the role of the group I intron, evolving towards proteinacious aminoacyl-tRNA synthetases (p-AARSs) (see Appendix 3).
We note that the mechanisms assumed for RNA coordinated to metal ion complexes follow this mechanistic course (a noncoordinated alkoxy nucleophile with a high p Ka value), so substituting the role of the 2′OH with a carbonyl hydrate site on the ligand provides a strategy for designing complexes effective for DNA hydrolysis as well.
In a former study by Dalby et al., the opposite was found: namely, randomly patterned poly methyl methacrylate) substrates, though with nanosized, not microsized features, substituted for the role of osteogenic supplements and induced the differentiation of MSCs to osteoblasts, unlike the chemically identical substrates with a perfect translational symmetry.
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