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The metal binding residues are either conserved or conservatively substituted hence preserving the ability of the proteins to bind metal ion.
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An understanding of the details of the mechanism of action of synthetic superoxide dismutase catalysts has made it possible to devise a computer modeling paradigm that allows one to design highly substituted (and hence highly stable) complexes that possess high catalytic activity.
Upon examination, many theses were outside the target years or from other institutions and were, hence, substituted.
Hence we substituted from (6.14) in (6.13), we get int_{Sigma}p u) (v-u),dSigma+(Nu,v-u)_{L^{2}(Sigma)}ge0 i.e. int_{Sigma}bigl(p u)+Nubigr) (v-u),dSigmage0 quad forall vin U_{mathrm{ad}} which completes the proof.
Hence we substituted from (6.15) in (6.14), to get int_{Sigma}p u) (v-u),dSigma+(Nu,v-u)_{L^{2}(Sigma)}ge0, i.e. int_{Sigma}bigl(p u)+Nubigr) (v-u),dSigmage0 quadforall vin U_{ad}, which completes the proof.
Hence, the substituted residues in PK-NCVI/Pk3a NS3 are not part of the functional regions of protein and are involved in the structure stability [ 11].
Hence, substituting into (3.20) gives (3.26).
Hence, substituting (3.8) in (3.3) and by condition (iv), we obtain (3.9).
Hence substituting the expressions for, and into the above equation yields (4.10).
Hence, substituting (7) into (16) gives the following ASEP expression for the considered dual-branch SSC receiver: (17).
Hence, substituting the bounds in (62) and (63) back into (61) and using Part of Lemma 5, we obtain.
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