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These could be derivatives or substituted compound classes that have been chemically modified to also contain substitutions that are typically not found in compounds assigned with the narrow definition.
Similarly, p-methoxy substituted compound 5f is more potent (56.23 % inhibition) as compared to the m-substituted compound 5e (44.21 % inhibition).
However, 3-ethoxy-4-hydroxy substituted compound, 5l and 3-methoxy-4-hydroxy substituted compound, 5k are the most potent ones with IC50 of 0.00005 and 0.00012 µM/ml respectively when compared to 5-fluorouracil (IC50 = 0.00615 µM/ml).
Yields were found to be independent of the nature of para substituents, but strongly decrease for an ortho substituted compound.
Intensive SAR studies on this new series led to the discovery of 3,4-dimethoxyl substituted compound 7b.
The phenyl substituted compound 2 assembled into corrugated tape structure through a R22(10) type dimer synthon and the benzyl substituted compound 3 assembled into 2-D layer structure through a C 5) type catemer synthon, whereas the butyl substituted compound 4 assembled into 2-D layer through both type synthons.
Similar(43)
Like chloro substituted compounds almost similar pattern of potency was exhibited by the bromo substituted compounds (8i, 8j and 8k).
The mechanism of electrode degradation differs for the binary and the substituted compounds.
On the other hand, single or poly substituted compounds on the benzene ring both showed good activity against FO.
The low electrode impedance of Cr substituted compounds can be responsible for the improvement of the electrochemical behavior.
The piperidyl substituted compounds such as 16d and 18d demonstrated strong ERα binding affinities and excellent anti-proliferative activities respectively.
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