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In the other variant the best residues were substituted at all contact positions except the reactive site where a Gly was substituted.
In the following, we use the aggregated substitution rate (delta _i) for an item, which corresponds to the likelihood that a delisted item gets substituted at all, and then assume that this aggregated rate is split equally among the remaining items, i.e., (gamma _{ji}=frac{delta _i}{{mathbb {N}}^+-1}), (forall j ne i) (cf. Kök et al. 2015).
This is not important in most cases, but some drugs should not be substituted at all.
[Ag CN 2]− reacted with cysteines substituted at all of the yellow- and orange-labeled sites, whereas [Au CN 2]− reacted only with cysteines at those sites indicated in orange.
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After making history in the seventh minute by scoring the first ever PSL goal, Kosmina was substituted at half time.
ESE sites were substituted at a mean rate of 5.4% as compared to 5.9% for non-ESE sites.
When it reacted with aromatic benzaldehydes forming derivatives substituted at position 5, however, all derivatives showed antimicrobial activity.
For Cys, Gly was the most common replacement (25%), while Ala, Val, Ile, Ser, Thr and positively charged Arg all substituted at frequencies of 8 to 12%.
All new peptides were substituted at position 2 with cis-1-amino-4-phenylcyclohexane-1-carboxylic acid (cis-Apc).
In eIF4E-1, a histidine is conserved in all sub-clades, but in eIF4E-2, cysteise isubstituteded at position 112.
Patients in this study were all taking brand hypertensive products before they had their medication substituted at least once into generics.
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CEO of Professional Science Editing for Scientists @ prosciediting.com