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It's not that bars aren't a good choice, it's that Yelp substituted the group's original question ("where can we go to keep talking?") with a different question ("what's a bar with good photos of cocktails?") all by shaping the menu.
Finally, we addressed the question whether substituting the β-sorting signal of PorB Ngo with the one of Omp85 Ngo can mediate integration of PorB Ngo into the OMM.
We anticipated a similar problem with our patients and have substituted this question with one on patient comfort.
To directly address this question, we substituted the bacterial plasmid DNA with various lengths of extragenic spacer DNAs between the 5′ and 3′ ends of the transgene expression cassette and determined the expression profiles using two different reporter expression cassettes.
To address this question, we substituted the odor stimulation with optogenetics-based light stimulation and gained unprecedented control over the spiking activity evoked in a genetically targeted OSN.
The Italians substituted the tomato for eggplant.
"There's no substituting the real deal.
For proxy reporting about a relative with AD, the question substituted "your relative" for "you".
Neither biology nor economics can substitute for the deeper ethical question: what kind of world do we want to live in?
They were substituted with questions about the dentists' estimation of what percentage of their colleagues behaves in a specific way, while confronting the situation that was described in each vignette.
Would your answer be different if the question were substituting one meal of vegan chili or broiled fish for your favorite burger?
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com