The uncorrected register data also overcounted by 0.4% the number on first-line treatment, and undercounted those on a zidovudine substitute and efavirenz substitute regimens by 3.6%and9.7%7%, respectively.
The only marked improvement was a reduced undercount of numbers on the substituted zidovudine regimen (from 3.6%to2.8%8%).
Accurate forecasting and ensuring availability of drugs is of key importance as patients may be triaged and delayed from substituting treatment regimens due to stock-out threats.
Study 28 (started in 2006), designed for the treatment of pulmonary tuberculosis, compared standard treatment with an experimental regimen substituting moxifloxacin for isoniazid.
This, together with the regular association of undifferentiated NPC with EBV infection, and the expression of immunogenic viral antigens in the tumor cells, has motivated strong efforts to develop strategies of immune intervention that could complement or even substitute current therapeutic regimens (reviewed in [21].
5-Fluorouracil could be substituted in FOLFOXIRI regimen by capecitabine, an oral fluoropyrimidine with similar efficacy.
This results suggested that biweekly or weekly docetaxel could be substituted for 3 weekly regimen if the response are similar.
It is likely that modification of the wTCF regimen by substituting an oral fluoropyrimidine for 5-FU would maintain activity, while potentially improving safety and convenience.
The incidence of CNS failures in metastatic melanoma was not significantly reduced and the clinical course was not modified substituting a dacarbazine-based regimen with a temozolomide based regimen.
Recently, capecitabine (X) and oxaliplatin (O) were found to be as effective as fluorouracil and cisplatin, respectively, when substituted in the ECF regimen for treating advanced gastro-oesophageal cancer (Cunningham et al, 2008).
In fact, our data show a continuous drop in resistance prevalence in the Italian HIV-infected population during a period when TA-sparing regimens substantially substitute TA-including combinations, mainly due to toxicity issues.
