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One questions the rationale for substituting IR residues for IGF1R residues, given that the activation mechanism is probably conserved (was it to insure folding?).
In short, neither lists nor averages substitute for an appeal to a defensible rationale or to a fair process for determining what should be covered.
His rationale was that one could substitute an untreatable condition for a treatable one - malaria being treatable with quinine.
This article discusses some of the rationale behind the use of skin substitutes and reviews some of the substitutes in use at the present time.
Moreover, publishing the MPC's minutes together with the policy decision is not a good substitute for a concise statement that summarises the rationale for the decision of the majority.
The rationale for its development as a bone substitute material is its similarity in composition to the bone mineral.
The rationale behind the above expression is easily understood after substituting (16) into (19).
By visualizing the position of the substituted amino acid, the other amino acids in the immediate environment, and the proximity of the substituted amino acid to the substrate and the cofactor, it is possible to suggest a physiochemical rationale for the effect, or the lack of any effect, of the substitution on enzyme kinetics as determined by the experiments of Takahashi et al.[4].
Yet if it manages to make progress in these areas, the rationale for sprawling big business groups sometimes almost like mini-states in their own right, as substitutes for the real thing will gradually disappear.
You can sort of see some rationale behind it; bee stings obviously have a definite physical effect on the body, they're 100% natural (another substitute for effectiveness), and a localised swelling certainly would remove wrinkles, albeit temporarily and painfully.
My rationale?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com