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For overcoming this problem, ANN can be used as a proper substitute method for response estimation.
Cook et al. noted that a noninvasive, substitute method for replacing the arterial input function is very desirable [ 26].
Estimated GFR (eGFR) from the Modification of Diet in Renal Disease (MDRD) Study reflecting serum creatinine (sCr) level, age, gender and ethnicity seems to be the most frequently advocated substitute method for measured GFR [ 3, 8].
Moreover, the results in our work confirmed statistically that TLC-densitometric method is accurate and can be used as a substitute method for the accurate assay of the acetaminophen in pharmaceutical dosage forms, for example, in situation when UV-spectrophotometer or HPLC-UV is not affordable in laboratory.
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Because chlorination of potable surface waters may be associated with increased risk of carcinogenicity, substitute methods for the routine disinfection of public water supplies are being explored.
Moreover saliva Lewis phenotyping through the hemagglutination inhibition test seems to be able to be used as a simple substituting method for determining the Lewis phenotype by the inference from Lewis and Secretor genotypes.
Thus, while human-factors engineering aims at substituting scientific method for guesswork, its specific techniques are usually empirical rather than theoretical.
However, substituting method detection limits for zero values led to systematically larger averages for sites that had high frequencies of PAH measurements below detection.
They substitute the methods for solving continuum problems.
It is premature to conclude that MIDAS should substitute manual methods for diagnosis or screening for CMBs in clinical practice.
Thus, it is concluded that nondestructive fluorescence spectroscopy can be used to monitor riboflavin content in yogurt, and that the suggested rapid method has the potential to substitute the standard method for analysis of riboflavin in yogurt.
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