Most commonly, haemostatic therapy in patients without preexisting haemostatic disorders aims to substitute key components (clotting factors and other blood components) by transfusion of allogeneic blood products, including fresh frozen plasma (FFP), platelet concentrate (PC), packed red blood cells (RBC) and, in some countries, cryoprecipitate.
Based on our analysis we conclude that when value is rapidly migrating across industries and between firms, proactively substituting key elements of the primary business model provides a better fit with the new value landscape than launching secondary business models in parallel.
In certain instances, altered peptide ligands (APLs) derived by substituting key amino acids lead to dissociation of effector T cell functions such as proliferation, cytokine production, and disease induction or cause immune tolerance [2], [3] and might have potential therapeutic value for immune-mediated diseases.
In these sequences, two of the UIM regions were rendered inactive by substituting key core UIM-defining residues and a conserved serine with alanine residues, shown to eliminate binding with a Ubl domain or ubiquitin.
The color symbols — circles, squares, diamonds, etc. — effectively substitute for key words, rebus-style, making comprehension much simpler.
However, they write, they were obliged to "substitute several key arguments of Perelman by new approaches based on our study, because we were unable to comprehend these original arguments of Perelman which are essential to the completion of the geometrization program".
K27M mutations in both genes substitute a key lysine residue on the histone H3 tail for a methionine, and have been shown to exert biochemical inhibition of the Polycomb Repressor Complex 2 (Presultinglting in a global loss of trimethylation of lysine 27 on all histones H3 molecules either wild types or mutated [ 34].
Watching Spall, I was reminded that I was recently twice conned by a man at the door seeking money first for a sponsored walk and then for a substitute latch-key.
Rooney, 27, who had grown frustrated at being dropped and substituted in key matches as Robin van Persie emerged as United's leading striker, told Alex Ferguson he wanted a transfer before Ferguson's surprise retirement as manager in May.
Shamoo and his colleagues modified the genome of the heat-loving Geobacillus stearothermophilus by substituting a key energy metabolism gene with the same gene from a close relative that thrives in lower temperatures (55 degrees C versus up to 73 degrees C).
Our findings provide an example for a non-conventional translocation mechanism and can explain how Kar3 substitutes for key functions of Dynein in the yeast nucleus.
