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To improve the mechanical integrity of the cartilage bone substitute interface, attempts have been made to generate a zone of calcified cartilage (ZCC) within the CPP cartilage interface, thereby mimicking the native joint architecture.
Making use of a simple mathematical model we have studied the stability of the aqueous-vitreous substitute interface.
Obviously, our model only represents in a highly idealized fashion the real behaviour of the aqueous-vitreous substitute interface in the vitreous chamber during eye rotations and we are perfectly aware that reality is much more complex than we have assumed.
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All underwent clinical and radiological follow-up at days 1, 90, and 365 to evaluate consolidation and bone substitute interfaces.
Alanine-scanning mutagenesis [ 12] is a popular method to identify hot spots by evaluating the change in binding free energy when substituting interface residues with alanine.
"We are not saying gaze tracking will substitute other interfaces — absolutely not.
In this study, we show that disrupting backbone H-bonding interactions by substituting dimer interface β-strand residues with proline (Pro) results in fully folded and functional monomers, by exploiting proline's unique feature, the lack of a backbone amide proton.
In no case, however, should software documentation substitute for poor interface design.
Dispensing with a traditional desktop display, the software substitutes an iconic interface intended to give students a simpler view of their programs and documents and a maplike view of other connected users nearby.
The trapped human CXCL8 monomer (L25NMe) was designed by substituting the dimer interface residue Leu-25 with N-Methyl Leu, which disrupts H-bonding interactions and introduces steric bulk about the two-fold symmetry point [10], [11].
Thus, hydrophobic residues at the interface were substituted with polar residues in attempt to create monomeric FPs [33 36].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com