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Alkylamino substituents, which were designed to bind in the S1 subsite of plasmin, were attached to the inhibitors.
The title compounds possess identical C-1 phenyl substituents which precludes the possibility of (Z)- and (E -stereoisomers.
These groups may contain basic or acidic substituents, which can serve as sites for electrostatic interactions with dyes having, respectively, acidic or basic groups.
The difference in activities between the target compounds was influenced by the substituents, which provided some hints for further investigation on structure modifications.
Nevertheless, the O H BDE of 4-HP was very sensitive to the substituents, which made NH2-derivatives of 4-HP very active as antioxidants.
This assumption was examined in allylations of various aldehydes with different substituents, which were synthesized from tryptophan methyl ester via four reaction steps in high yields.
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It is noted that the electrostatic interaction increases with the number of meso-substituents, which was favourable for porphyrin binding.
We investigated the structure activity relationship of KNT-127 (opioid δ agonist) derivatives with various 17-substituents which are different in length and size.
The spectroscopic studies and theoretical calculations indicate that the photophysical properties of these aza-BODIQUs can be tuned by the appended aryl-substituents, which would be useful for rational design of boron fluorine complexes with high emission quantum yield for organic light-emitting applications.
Thus, Asn residue may be a promising substituent, which can potentially diversify posttranslational chemistry in GFP-like proteins.
Unlike molecules containing a C4′-O-aryl substituent, which have also been used for ureter visualization, UL-766 is not reactive towards glutathione and the cellular proteome.
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