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Replacement of the 5-nitroso substituent with ketone, oxime and semicarbazone groups essentially abolished activity.
This activity was reduced upon replacing this substituent with another tricyclic aliphatic one as in compound 9.
Removal of the allyl substituent with RhCl3, hydrogenation of the ring system, and re-attachment of the allyl moiety provided the allyl derivatives 4a and 4b.
A previous study showed that a substituent with an α-hydrogen atom on an o-position of a phenolic antioxidant enhances the antioxidative activity.
We compare the traditional F8T2 derivative with octyl substituent with two modified species, one containing solely 2-ethylhexyl side-chains and another with both types randomly distributed.
In particular, if a drug has a long acyclic substituent (with high flexibility), the coverage of RCDTC (with less than half number of RC in RCPCA) was superior to the coverage of RCPCA.
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Substituents with I-effect activate the toleune towards anodic attack, substituents with I-effect deactivate the aromatic system.
Replacing the tert-butyl substituents with methoxy substituents at the para positions of the biphenyl moieties improved the enantioselectivities.
In contrast, incorporating aryl substituents with strong electron-donating ability decreases the fluorescence quantum yield.
Introducing bulky substituents with weak electron-donating ability enhances the fluorescence quantum yield from 23%to87%7%.
The bulky substituents with more steric hindrance of the complexes had relatively lower activity.
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