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Discover Ludwig"substantively modified" is an acceptable and usable expression in written English.
You can use it when you want to indicate that something has been modified or changed in a meaningful way. For example, "The law was substantively modified to include stricter penalties for violators."
Exact(3)
The basic insights and the framework laid out in On Learned Ignorance is never discarded and never substantively modified.
Of the previous generic accounts, 95percentt have been substantively modified, and there are 80 new ones among them, three remarkable, large ungulates recently discovered in the forests of Indochina.
Using a backward selection process, all these covariates were added to the initial model, but only covariates with significant independent associations themselves (p < 0.05), or which substantively modified HTLV incidence ratio, were retained in the final model.
Similar(57)
Use of hydrocortisone did not appear to substantively modify this relationship [ 5].
Varying these definitions does not substantively change our results.
If you want to substantively change the DoD, the budget is the best way to go.
Genetically modified soy foods may modify you.
Artwork: Credit Beejoir, modified.
Well, modified push-ups.
"Tofu, modified?" Oh, dear.
Credit viltsi.deviantart.com, modified.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com