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A second and more substantive variant of country music arose in the 1930s in the Texas-Oklahoma region, where the music of rural whites was exposed to the swing jazz of black orchestras.
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With the current version of ESPRESSO, it is not possible to carry out power calculations, for genetic association studies, that precisely represent reality, i.e. when an analysis might choose to model a substantive number of genetic variants at the same time.
The five remaining candidates (cpOYE291, -292, -303, -305, and -307) were selected from sector III, the region with variants that showed the most substantive catalytic improvements.
However, the physical distance of a variant to a gene is not substantive evidence of causality.
The algebraic strength of GEM, and of its weaker finitary and infinitary variants, is worth emphasizing, but it also reflects substantive mereological postulates whose philosophical underpinnings leave room for considerable controversy well beyond the gunk/junk dispute.
Substantive concern: What the paper lacks is clear cut experimental evidence showing that a single copy of a CMT2B rab7 variant (or protein expression equivalent of it) in a heterozygous mutant background represents a reduction in Rab7 activity and predisposes neurons to degeneration.
Since there are no prior reports of significant and coordinated perturbations of fatty acid and cholesterol biosynthetic pathways with IGF-1 in muscle cells, these findings provide a substantive expansion of our understanding of IGF-1 action and the signal transduction pathways mediated by it, its variants and insulin.
"Be substantive".
There are substantive issues.
It was substantive.
To be made substantive.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com