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This discussion is not meant to be exhaustive, but highlights areas in which generally held assumptions require more substantive validation.
These findings are consistent with prior reports and provide substantive validation of the model used in the current studies [ 33].
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The miniaturization of sequencers with the advent of Illumina's MiSeq and Life Technologies Ion Torrentt is making HTS accessible to many more customers in clinical diagnostics, although incorporating these devices into clinical workflows will require substantive testing and validation.
What will validation validate?
Substantive discussions of surrogate endpoint validation began in the late 1980s and early 1990s partly driven by the need to find valid biomarkers for Acquired Immunodeficiency Syndrome (AIDS) randomised controlled trials.
Development and validation of the LCAS followed the three-stage process (substantive, structural, and external stages) detailed by Benson (1998; Figure 1).
This is of substantive interest to understand household behavior and also a further step in the validation of the house price expectation responses.
However, these observations are based on small sample sizes, especially those relating to H2 allele, and will require validation in further, and larger, cohorts before they can be considered to be substantive.
"Be substantive".
There are substantive issues.
It was substantive.
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