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The types of criteria are not specified, other than they should be few and address substantive threats to the validity of the study results.
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The proposed legislation would allow for the termination of a pregnancy in cases where there is a real and substantive threat to the life of the woman, including from suicide.
George Joffe, a Cambridge University scholar who has studied the Libyan tribes, said in an e-mail that the government plan to have tribes do the fighting "sounded more like bombast to me than a substantive threat".
The proposed legislation would allow for the termination of a pregnancy in the limited number of cases where there is a real and substantive threat to the life of the woman, including from suicide.
In the adjunctive armodafinil group, 1 patient had an SAE coded using the Medical Dictionary for Regulatory Activities preferred term of "bipolar I disorder" (specifically, exacerbation of bipolar disorder (mixed episode with psychotic symptoms)), accompanied by a suicide attempt, with no substantive threat to life; both SAEs resolved with no residual effect.
Therefore, treatment side effects are likely to remain a substantive threat to adherence.
As quality checklists are poorly correlated with validity of studies and often measure the quality of reporting rather than that of the underlying research [ 35, 36], we limited these criteria to those we considered a substantive threat to the validity of results.
The substantive health threat contained in the concept of "risk compensation" is that as a result of using PrEP (or other risk-reduction measure), people who are already at high risk of HIV acquisition will increase their risk practices, and that the protection offered by partially effective risk-reduction measures such as PrEP will not be effective enough.
Former bureau officials said that keeping even preliminary inquiries open past the point where they established substantive connections to security threats risked overtaxing law enforcement resources and missing genuine threats in the shuffle.
The FBI "determined that contact was minimal and did not constitute a substantive relationship or a threat at that time," Ronald Hopper, an FBI official, told reporters in Orlando.
Hopper told reporters in Orlando that agents "determined the contact was minimal and did not constitute a substantive relationship or a threat at that time".
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