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By inhibiting the first and rate-limiting step in the RAS system (conversion of angiotensinogen to angiotensin I), aliskiren may block the generation of angiotensin II more completely than ACE inhibitors because there is no other substantive pathway for angiotensin I production (Stanton 2003).
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Her vision represents a pathway to substantive change in California.
2. Prosecutorial discretion confers no substantive right, immigration status, or pathway to citizenship.
Developmentally arrested, non-feeding larvae would be expected to be dependent on stored energy reserves and lipid metabolic pathways; accordingly, the KEGG biochemical pathway mappings show a substantive number of clusters for fatty acid metabolism especially with the A. ceylanicum iL3 clusters (Table 4).
Our data reveal dual-pathway mitosis as a substantive biological strategy that improves both the speed and fidelity of mitosis, thereby reducing the risk of cancer and other genetic diseases.
This rhetoric distracts from a substantive debate on policies that can create fair pathways to citizenship for aspiring Americans, and flippantly devalues millions of first-generation Americans.
Since there are no prior reports of significant and coordinated perturbations of fatty acid and cholesterol biosynthetic pathways with IGF-1 in muscle cells, these findings provide a substantive expansion of our understanding of IGF-1 action and the signal transduction pathways mediated by it, its variants and insulin.
Our data reveal dual pathway mitosis in a new light, as a substantive strategy that increases both the speed and the fidelity of mitosis.
The exact molecular mechanism by which copper becomes deficient in the livers of ob/ob mice is uncertain at present, but could mirror that which causes myocardial copper deficiency and cardiac damage in diabetic cardiomyopathy, where there is substantive evidence that diabetes can evoke regulatory defects in many of the pathways that mediate myocellular copper uptake and distribution [13].
Furthermore, the substantive area of responsibility of the agent should be as close as possible to intervention actions needed, where the best practice pathway can value add, and the project can value add by providing enough staff time for best practice actions to occur.
The definition is not as important as the substantive conclusion: The fact that it is possible to restore a previously existing structure by many non-trivial mutational pathways is sufficient to cause pronounced antagonistic directional epistasis.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com