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I do not accept that as a valid reason for refusing to offer any substantive justification for its decision to kill him.
And, despite his rhetorical obsession with "efficiency" elsewhere, he doesn't even offer a substantive justification for why defense should get a free pass, or why national security requires us to spend four hundred billion dollars more each year than we did a decade ago.
The "administrative closure order" came with no details or substantive justification.
The deviation from any of these points should be reasonably defended by the study sponsor to the ethics committee, and the ethics committee should find substantive justification for the said deviation.
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Some critics of the principle of double effect have maintained that when double effect has been invoked, substantive independent justifications for causing the kind of harm in question are implicitly relied upon, and are in fact, doing all of the justificatory work.
Thus, among such views there are some such as Annis', which he intends as an alternative to foundationalism and coherentism which are obviously concerned with making substantive claims about knowledge or justification itself.
This number will also allow us to evaluate the secondary objective of the trial; to estimate the potential treatment effect size as the basis and justification for a substantive trial.
But Mr Obama has chosen this moment to tackle a collection of problems, such as health care and environmental regulation, that have defeated much less overburdened administrations.The administration advances two justifications for this, one substantive (you can't fix America's economy without also dealing with its long-term problems) and one political ("Never waste a good crisis").
Later generations of Protestant thinkers sometimes resorted to scholastic philosophical definitions similar to those of medieval theologians; in such definitions justification became the material (or substantive) principle of the Reformation, while the matter of scriptural authority became the equally important formal (or structural) principle.
This philosophical modesty freed them to look more closely at the details of substantive moral views than philosophers seeking grand justifications tend to do, and to uncover more of their underlying structure, as in the principle of organic unities.
For the distinction between definitional and substantive questions, see Alston's essay "Concepts of Epistemic Justification," in Alston 1989 pp. 81-114, Goldman 1979, and Steup 1996, chapter 2. 10.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com