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We argue there are strong theoretical reasons to expect that the magnitude of this double standard varies across substantive domains, as well as among parents and non-parents.
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The appropriate level of spatial and temporal resolution for indicators varies, however, with the substantive domain.
With the flexibility comes the potential for incorporating information regarding the substantive domain and the observational setting.
Severe diffuse reactive astrogliosis also consists of changes (up- or down-regulation) in gene expression with pronounced up-regulation of GFAP expression and hypertrophy of cell body and processes, but in addition includes astrocyte proliferation and loss of individual astrocyte domains with substantive intermingling and overlapping of neighbouring astrocyte processes.
Mild to moderate reactive astrogliosis consists of changes (up- or down-regulation) in gene expression and hypertrophy of cell body and processes without substantive loss of individual astrocyte domains and little or no astrocyte proliferation; up-regulation of GFAP expression is prominent.
In addition, glial scar formation progresses beyond these changes with groups of reactive astrocytes that exhibit pronounced overlapping of reactive astrocyte processes, obliteration of individual astrocyte domains, evidence of substantive astrocyte proliferation, and the clear formation of dense, narrow, and compact glial scars (Fig. 4d).
Val McDermid puts the same substantive thought into A DARKER DOMAIN (Harper/HarperCollins, $24.99), using a missing persons case to revisit the devastating 1984 coal miners' strike that tore apart a working-class Scottish community.
Our comparison of the percentiles of the distributions of the plausible values based on the five rotation models and the original plausible values revealed no substantive differences in any of the domains.
Consequently, substantive expertise, based on context-specific or domain knowledge and knowledge-based heuristics, is a primary concern, preferably to be brought together in a multidisciplinary context of collaborative action - enhancing chances at success.
Nevertheless, depressive symptoms explained a large proportion of the variance in some of the cognitive domains, indicating that the effect is substantive.
In mild or moderate reactive astrogliosis there is variable up regulation of expression of GFAP and other genes [ 226], as well as hypertrophy of cell body and processes that can vary in degree but that occurs within the domains of individual astrocytes [ 257] without substantive intermingling or overlap of processes of neighboring astrocytes or loss of individual domains (Figs. 3b, 4b) [ 226].
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