A barely adequate paper would provide a summary of the readings; a superior paper would identify weaknesses, unresolved questions, and the substantive implications of any deficiencies.
Adiponectin deficiency makes a substantive contribution to the development of NAFLD and NASH in ob/ob mice, and hepatic structure and function are largely restored by adiponectin treatment [4].
Copper concentrations in dried-defatted tissue were markedly lower in ob/ob mice as compared with matched controls (Fig. 1B), providing substantive evidence for genuine hepatic copper deficiency.
The shorter treatment course is an important practical advantage in people who do not have G6PD deficiency, but the longer half-life may have more substantive consequences if given inadvertently to people with G6PD deficiency.
Although no follow up studies have reported substantive outcomes, it is plausible that the iron deficiency associated with immediate cord clamping could leave the child more susceptible to infection, and with impaired growth and development in early childhood.
Conclusions FDA generally issued complete response letters to sponsors for multiple substantive reasons, most commonly related to safety and/or efficacy deficiencies.
The shorter treatment course is a practical advantage, but the longer half-life could may have more substantive consequences if given inadvertently to people with G6PD deficiency.
By seeking more substantive feedback, students can focus mood board creation skill development on specific deficiencies.
The exact molecular mechanism by which copper becomes deficient in the livers of ob/ob mice is uncertain at present, but could mirror that which causes myocardial copper deficiency and cardiac damage in diabetic cardiomyopathy, where there is substantive evidence that diabetes can evoke regulatory defects in many of the pathways that mediate myocellular copper uptake and distribution [13].
