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"substantive changes" is correct and can be used in written English.
You can use this phrase to refer to important or significant changes that have been made. For example, "The committee has made many substantive changes to the proposal."
Exact(57)
Yet substantive changes have been minimal.
Indeed, the Jets have toyed with more substantive changes.
Mine would be a lot of substantive changes.
The panel called for "substantive changes" in the second phase.
So substantive changes are unlikely to take place.
Rouhani has to deliver substantive changes otherwise it's not going to work".
Mr. Sharon says he accepts the plan, but is seeking substantive changes.
He also pledged "substantive changes to improve the reforms, based on what we hear".
Without substantive changes the policy cannot meet Australia's promised emission reduction targets.
By contrast, Levitra, like Viagra, has been making more substantive changes in its ads.
To say nothing of the substantive changes the Obama Administration will bring.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com