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Fiyaz Mughal, the founder and director of the community cohesion group Faith Matters, welcomed the initiative but said there would be "substantive barriers" to its success.
They concluded that lateral cell-cell junctions did not present substantive barriers to hydrodynamic flow between cells.
Cardiologists observed that the cost of treatment and the impact of formularies and healthcare plans on patient finances represent substantive barriers to optimal patient health outcomes.
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This is a point about terminological clarity, not a substantive barrier to discussing such asymmetric relations.
They reported that a substantive barrier to optimal patient management is the lack of an effective means to monitor CVD progression.
The lack of consensus on what is appropriate methodology remains a substantive barrier to understanding the role of osteopathic medicine in chronic non-specific lower back pain, which forms a major presentation to osteopathic clinical practice.
A summary of the thirteen substantive gaps, challenges and barriers that were identified is presented in Table 4.
A crucial question that is then raised is what the key reasons for or barriers influencing these substantive gaps in service utilization are.
In particular, a substantive reduction in capacity associated with anthropogenic barriers can reduce the effective population size and consequently genetic variation within the population.
The problems encountered in getting that substantive work published illustrates the kind of barriers that have to be overcome when challenging ingrained dogmas.
This, we felt, would make barrier mapping a subjective task unless substantive work could be done to explore the extent to which interventions address specific barriers.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com