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I "tidy" Thoreau's manuscript no more than necessary to make his work in progress accessible to the reader, and for each of my substantive alterations, I present an editorial note in the back of the volume.
The essay cites Treasury Department rulings that buying the rights to books not yet written, or making substantive alterations or enhancements in written works from those countries, might be illegal and punishable unless each transaction was licensed in advance by the department.
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Previously, we implemented subtree-based local RNA structure alignment by a minor adaptation of the CM's generative model that required no substantive alteration of the CYK algorithm.
While IL-10KO mice showed no substantive alteration in synovial Il6 or Tnf over 28 days, there was a twofold increase in Il1b over that seen in WT mice three days after arthritis induction, which had resolved by day 28.
Surprisingly, our evaluation of previously characterized TCR structures indicated that the absence of a S107 side chain in TRBV13-2+ TCR did not lead to substantive structural alterations.
Banned activities include, she wrote, "collaboration on and editing of the manuscripts, the selection of reviewers, and facilitation of a review resulting in substantive enhancements or alterations to the manuscripts".
The Treasury office ruled that the institute could edit a manuscript from a country under embargo, and engage in peer review, but that making any "substantive or artistic alterations or enhancements of the manuscript" would be illegal without a license.
The three dissenting judges said that the Ring decision should not apply retroactively because it announced neither a new substantive rule nor a fundamental alteration of a procedural one.
This demonstrates that there are substantive changes in global DNA methylation in response to diabetes, suggesting major alterations in genomic integrity and gene expression.
Although details of concurrent and independent genetic alterations in human breast epithelial and stromal cells remain to be resolved, there is now substantive experimental evidence that stromal cells and the ECM interact both directly and indirectly to influence the phenotype of transformed breast epithelial cells.
"Be substantive".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com