Sentence examples for substantiating the need from inspiring English sources

As for HER2 expression, significant spatial and temporal inter-metastatic heterogeneity of ER-expression has been reported (Hoefnagel et al., 2013), substantiating the need for repeated whole-body assessment of ER-status by hybrid imaging.

A growing number of failing clinical trials for cancer therapy are substantiating the need to upgrade the current practice in culturing tumor cells and modeling tumor angiogenesis in vitro.

Furthermore, due to considerable intra-regional variation, [ 10, 13], national data on primary CDs may not reflect local trends, substantiating the need to monitor rates at the individual hospital level [ 14].

Moreover, as previously shown for yeast Ire1, only one stem loop can be accommodated in the dimeric RNase-active site [ 21] and human IRE1 has a highly similar geometry (PDB ID 4Z7G) [ 31], further substantiating the need for independent RNase-active sites.

Our study substantiates the need for reassessment of the safety/toxicity of metal oxide ENPs.

The ubiquitous nature of embedded systems substantiates the need for design and development methods that yield the lowest possible power consumption.

This has substantiated the need to develop a new approach to achieve nitrogen (N) load reduction to the aquatic environments with lower costs to farmers.

This paper substantiated the need for the notion of ideal failure model of structure to be introduced when the Finite Element Method (FEM) and Additional Finite Element Method (AFEM) are used for nonlinear analysis at limit states.

The paper first substantiates the need to develop a long-term research plan for barriers, traps, and fishways by summarizing (i) current management challenges, (ii) the barrier, trap, and fishway options being used to meet these challenges, and (iii) the key uncertainties in our knowledge regarding these options.

Given that a number of stem cell based clinical trials are being conducted or planned in USA and a recent report in PLoS Medicine showing the dangers of grafting an inordinate number of cells, these data substantiate the need for careful cytogenetic evaluation of hNPCs (fetal or hESC-derived) before their use in clinical or basic science applications.

However, Yu and colleagues emphasize further discussion and substantiate the need for a prospective randomized controlled trial on this subject.