The chapter further ponders how the science of evolution of carbon in the universe would be pivotal for substantiating the rationale that life on Earth is not a localized phenomenon, but a marked legacy of the primeval cosmic carbon.
With this series of papers, evaluators are being called to substantiate the rationale and warrant for their own evaluative actions in ways parallel to how evaluators question the logic of program interventions, both as designed and as implemented.
Thus, the convergence of a common cellular response for B49Mod1-targeting of similar oncogenic behavior in different cell lines of different subtypes substantiates the rationale for further development of B49Mod1 as an anti-adhesion and anti-cancer reagent, as well as potential treatment for breast cancer.
Skinstage activation of parasite-specific Treg-based systemic immunosuppression provides a fundamentally new, experimentally widely substantiated, immunological rationale, and precise focus, for research and vaccination strategy leading to potentially accelerated malaria eradication.
However, we would need to conduct further research to substantiate this rationale.
We speculate that this difference reflects how asymmetrical use of the upper limbs is more common than for the lower limbs, but further research is necessary to substantiate this hypothesized rationale for the differences noted.
However, regulatory authorities often require that a dietary supplement product be registered or licensed with documentation substantiating the safety, scientific rationale for claims, and quality specifications for the finished good and/or individual ingredients.
Review of the medical literature did not substantiate efficacy or, in most cases, any rationale for the advertised treatments.
However, further research is required to substantiate these speculations and to explore the rationale for dispensing all inpatient medication as OSD supplies, even for inpatient medication which is extremely unlikely to be continued at discharge.
Although the rationale behind this approach has been substantiated in experimental systems6,7 results with human mammary carcinomas are inconclusive8 16, probably because of insufficient specificity17 and sensitivity of the radioimmunological protein assay on which this method depends.
However, GlaxoSmithKline experiences in developing novel antibacterials from a genomics-driven target-based approach have shown the importance of multiple analysis perspectives and the need to substantiate initial bioinformatics target identifications with additional biological rationale [ 16].
