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The experimental results substantiate the validation of the calculation and further identified the DDT mechanism.
Such integrative efforts substantiated with experimental validation present a highly promising systems approach for elucidating the regulatory determinants of secondary metabolism.
Despite this non-ideal configuration, the experiments provided a validation of the design, substantiated by an excellent agreement with numerical simulations.
For epigenetic associations to be substantiated, the onus still falls on validation of primary associations in secondary panels of subjects, ideally followed by the demonstration of effects in isolated cells from cases and controls.
This is only one form of validation and not all guidelines can be substantiated with scientific evidence or best practice.
Social work professionals often refer to people achieving validation, increased self-esteem or having their case substantiated when defining positive outcomes.
While many of these innovations have demonstrated promising outcomes in a small scale, laboratory settings, validation of these for their practical viability must be substantiated.
Therefore, while encouraged that several potential targets presented here are also substantiated by earlier computational studies using different approaches, we feel it is important to further extend and rationalize in silico target validation with current knowledge on the biology, biochemistry and disease pathology of M. tuberculosis.
No allegations were substantiated.
Only one has been substantiated.
One complaint was substantiated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com