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Thus our understanding of the biological pathogenesis needs to be substantiated to enable development of more targeted treatment options with improved efficacy.
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The U.S. Surgeon General's 1964 report on smoking and health helped change congressional and agency priorities to enable research substantiating the reports' claims, and mobilized medical, public health, and civil society efforts against early death and disease.
The methodology used entailed a wide consultative process with various stakeholders/partners to enable appropriate data collection and generate evidence to substantiate all findings, ensuring that the data collection methods and data analysis is credible and accurate.
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