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Expression and genetic analyses have substantiated the involvement of all six TF families in flower development and reproduction [ 21- 24].
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We have now demonstrated that the orexigenic effect of ghrelin is absent in CB1-KO mice, substantiating the involvement of the cannabinoid system in the effects of ghrelin.
Therefore, to substantiate the involvement of a retrovirus in multiple sclerosis we sought for linkage disequilibrium between markers in TRIM5 and disease.
In order to substantiate the involvement of dynein-dynactin complex, we first confirmed that Lis1, Dmn, and p24 are required for the dendritic restriction of Dscam[TM1]::GFP using reagents independent of our genetic screen.
Additionally, we showed that S100A4 release induced by both VMR-CM and recombinant RANTES could successfully be circumvented by anti-RANTES, but not by control IgG which substantiates the involvement of RANTES in this process (Fig. 1B and C).
To further substantiate the involvement of 5-LO in the dexamethasone-dependent effect on Aβ formation, we next used MEFs isolated from transgenic mice over-expressing the Swedish APP mutant (i.e., Tg2576) [15], or Tg2576 genetically deficient for 5-LO (Tg2576/5-LO−/−) [11], and incubated them with dexamethasone.
These results together further substantiate the involvement of IFNα in the development of various autoimmune disorders.
This result substantiates the involvement of S100A8 during the progression of NMIBC.
These results substantiate the involvement of phenylpropanoid and particularly flavonoid pathways in safflower during wounding and especially salinity stress.
To further substantiate the involvement of autophagy in the progression and chemotherapeutic response of ovarian carcinomas, we correlated the expression of LC3 with the clinical outcome.
To further substantiate the involvement of GSK3 in mTORC1 signalling, we utilized lentivirus-based shRNA technology to generate L6 myotubes exhibiting stable knockdown of both GSK3α and GSK3β.
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