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These results were substantiated in a larger study that employed 10 mice for each variant.
Whether our findings can be substantiated in a larger patient series has to be demonstrated in future trials.
For BRCA2 mutation, an association with tubular/lobular carcinoma has been suggested, but not substantiated in a larger Breast Cancer Linkage Consortium study.
Although our data provide only weak evidence for a difference in frequencies at the population level, the number of deleterious mutation carriers was low and the results may yet be substantiated in a larger study using pooled data.
This observation, that has to be substantiated in a larger number of samples, may explain the discrepancy between the relatively high in situ expression of GD2 compared with established cell lines and further encourages therapeutic targeting of GD2 in Ewing sarcoma.
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Although this has to be substantiated in a large number of tumours, vascular density might be an additional prognostic factor indicating the probability of malignant progression of KA into SCC.
The heterogeneity of LVV was substantiated in a report on 72 cases of, during life, documented GCA with aortic and extracranial large vessel involvement.
This was substantiated in a follow-up study (15 ).
These findings have been substantiated in a number of other studies [ 3, 4].
However, this finding could not be substantiated in a later and more thoroughly performed study [ 19].
Farkas-Himsley substantiated in an experimental study, that the cells of colorectal adenocarcinoma were more sensitive to bacteriocins when compared to normal cells of large bowel mucosa [ 31].
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