Notably, the mechanism underlying the activity of miR-21 as a direct inhibitor of RECK and TIMP3 was substantiated by directly targeting the 3′-UTR of the mRNAs of the two transcripts [ 17].
Of these, only the involvement of the chancellor, John of Alleux, is directly substantiated by the textual evidence: the introductory letter to Tempier's condemnation stipulated that offenders had to report either to the bishop himself or to the chancellor.
As shown in Fig. 6B,C, this hypothesis is directly substantiated by our experimental data.
Importantly, this cannot be directly substantiated in the current study as bed capacity data was not a collected variable.
"Some of the things that have been alleged will be difficult to substantiate without speaking directly with the people who filed the lawsuit," he said.
Together with our previous data in Figure 2, our results substantiate that MdOS directly inhibit cellular tyrosine kinase activity independent of extracellular activity, and strongly support that MdOS behaves distinctly from the conventional oligosaccharides.
Our findings provide further characterization of these alkali-sensitive sites by using enzymatic assays to directly substantiate that such lesions are single or diribonucleotides that are covalently incorporated into genomic DNA.
The Jena group's apparent contradiction in the behavioral role of DM5 needs to move beyond correlation and be substantiated with manipulation of DM5 directly in a behavioral analysis.
This theory is substantiated with much direct and indirect evidence.
This result implies that C/EBPβ mediates Zeb1 expression, which is substantiated by the fact that C/EBPβ directly targets the Zeb1 gene in 3T3-L1 pre-adipocytes.
