The main conclusion, which is substantiated through application examples, is that robust and reliable estimation applications based on first principles models of considerable complexity, can be designed and implemented for use in an industrial environment.
Hence, results substantiate the application of adsorption isotherms for designing nanoparticles possessing potential to exhibit prolonged circulation when administered in vivo.
Both the Rapoport and the Du groups propose various scenarios and hypotheses that claim to be consistent with their in vitro and in vivo observations, but which are difficult to prove in vivo; yet these hypotheses must be substantiated before clinical application can commence.
Final real world verification from both applications substantiated the potential of our proposed methodologies to reduce subjectivity in stream classification.
Therefore, ontology evaluation can be further substantiated by an application-based evaluation (see Figure 2).
Complex observations are contextualized in the framework of diagnosis of active systems and substantiated by a sample application in the domain of power transmission networks.
The interest in microfluidics and surface patterning is increasing as the use of these technologies in diverse biomedical applications is substantiated.
This substantiates the formal application of the Cottrellian diffusion approach to determine D during the processes of intercalation and deintercalation, accompanied by first-order transitions; however, involvement of the slow interfacial kinetics in the measured response should be adequatly taken into account.
The principles of the magnetic propulsion (Prog Aerospace Sci 2001 37 245 61) allow to substantiate the proposed application and variant of design of the magnetic flight vehicle, to clarify its advantageous properties and to determine the main problems to be solved for its creation.
Finally, to substantiate a practical application of the herringbone structure for positioning, cells were randomly introduced into a microfluidic device, containing an array of trapping structures together with a series of herringbone structures along the channel.
