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"Wakefield's greatest offence was his failure – over 12 years – either to substantiate a hypothesis with major consequences for child health or to withdraw it".
To substantiate our hypothesis that PKCζ is an active component of LTD signalling, we tested whether LFS of hippocampal slices, which leads to NMDAR activation and LTD induction, regulates PKCζ activity.
But he could not substantiate his hypothesis with a sufficient number of triads, and his findings were regarded in his time as merely interesting curiosities.
Further studies combining QST, electrophysiology, biopsies and imaging tests will be needed to substantiate this hypothesis.
Altogether, the evidence available to substantiate the hypothesis of prevalent under-investment in CVT is not very compelling.
The best way to substantiate a hypothesis is to try to falsify it ad modum Popper [70].
Although, this method is promising but it needs more studies to substantiate the hypothesis of oil extraction from ionic liquids.
Therefore, simulated data were generated in order to substantiate this hypothesis, and the results obtained from the analysis seemed to support it.
The aims of this study were to substantiate our hypothesis and to further evaluate the possibilities of a vaginal approach to colpotomy.
Since acid treatment is assumed to simulate animal's digestion, our results substantiate the hypothesis of animals as seed propagators of Adansonia.
The data substantiate the hypothesis that anchoring of GR by nestin compromises its growth suppressive functions.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com