Given that a number of stem cell based clinical trials are being conducted or planned in USA and a recent report in PLoS Medicine showing the dangers of grafting an inordinate number of cells, these data substantiate the need for careful cytogenetic evaluation of hNPCs (fetal or hESC-derived) before their use in clinical or basic science applications.
However, Yu and colleagues emphasize further discussion and substantiate the need for a prospective randomized controlled trial on this subject.
These findings substantiate the need for development and implementation of a tobacco control program in the area.
The data of this study substantiate the need for specification of regional targets for reducing mortality related to diabetes, as has been previously recommended [ 26].
Reported site-specific changes in protein glycosylation in cancer diseases substantiate the need for their quantitative analysis in terms of disease detection and classification.
As will become clear, the social science theories help to explain the lack of improvement in diversity and serve to substantiate the need for a new supplementary coaching model.
The clinical impact that storage lesions have on RBC survival in transfused patients is debatable and therefore the evidence to substantiate the need for a shorter storage period is unsatisfactory.
These findings in an animal model extend the repertoire of environmental conditions that preimplantation embryos are sensitive to and substantiate the need for broader analysis of underlying molecular mechanisms and applicability across species, including humans.
Our results substantiate the need for ongoing support for individuals with specific chronic disease conditions (e.g. diabetes and asthma) to enhance their quality of life, and indicate how important early intervention and prevention are for these conditions.
However, the influence of shortening on clavicular and scapulohumeral movement and on functional outcome has not been sufficiently studied to substantiate the need for primary operative reduction and fixation of displaced clavicular fractures in order to prevent poor functional outcome.
These findings reinforce community concerns of exposure and substantiate the need for larger, well-designed environmental exposure and health effects studies to determine the influence of these facilities and their contaminants on health in adjacent communities.
