To further substantiate the relevance of S29 phosphorylation in vivo, we compared the phosphorylation patterns of the S29/S294/S300A mutant with a S294/S300A mutant in the light and after extended night treatments in the genomic complementation lines.
This result further substantiates the relevance of heparanase for hematopoietic engraftment.
Although substantiating the relevance of the G5 sequence composition in GDP release, these studies have exclusively been focused on the second residue of the motif.
The cognitive debriefing interviews on the male and female versions of the PE measures substantiated the relevance of control of ejaculation, satisfaction with intercourse, personal distress, and relationship difficulty among the participants.
Substantiating the relevance of these observations to later α-syn aggregation in MSA, p25α co-localizes with α-syn in GCIs and is a potent inducer of α-syn aggregation in vitro[ 30- 32].
Elements of this notion in relation to self-care [ 24- 27], provided an important context and substantiated the relevance and meaning for the key findings of our study [ 22].
We use findings from the literature to substantiate the neuropathologic relevance of MLK3 to neurodegenerative disease, with an emphasis on Parkinson's disease that shares a number of important phenotypic and neuropathologic characteristics with HAND.
One previous work in which this same mechanism has been studied in an AL model at the PN stage, is by Av-Ron and colleagues [37], [38], who also substantiate a biological relevance of disinhibition occurring in PNs.
However, additional biochemistry studies are needed to substantiate the biological relevance of SRM1, for example to verify if the Rad51-G143P mayant may exhibit other defects, such as in polymerization, ssDNA binding, or interaction with mediator proteins.
In order to substantiate the physiological relevance of these findings, LXRα mediated pathways were investigated in miR-206 KO mice.
To further substantiate the biological relevance of UNC-45 oligomerization for muscle function, we tested whether the interface mutations compromised sarcomere organization when expressed in wild-type worms.
