To further substantiate this function, miR-155 knockdown WM cells were investigated and showed impaired homing and trafficking when injected into mice.
Proline, total soluble sugar and amino acid contents were measured in WT and transgenic plants to substantiate the function of the SbSOS1 gene.
Finally, to substantiate the function of UXT in modulating Notch signaling in vivo, we treated Tg kdrl EGFP) s843 embryos with 60 µM DAPT or DMSO at 12 hpf, and then observed ISV formation by confocal microscopy at 30 hpf.
However, since results obtained with pharmacological inhibitors should be interpreted with a certain caution due to their potential nonspecific effects, we sought to further substantiate the function of HtrA2/Omi in TNF-induced necroptosis by selectively targeting its expression using RNA interference.
Thus, the oncogenic and suppressive functions of Nkx2-1 in the same tumour type substantiate its role as a dual function lineage factor.
These findings substantiate the stabilizing function of ASCs.
In order to extend these findings and to substantiate a possible function of QC in pE-Aβ generation in vivo, we studied LC, a brainstem nucleus known to be severely affected in AD.
Many clinical and preclinical studies carried out in the past 2 decades have helped to substantiate the role of PS in supporting cognitive function.
FA-dependent exposure response relationships have not been substantiated from lung function effects in controlled chamber studies neither in healthy adults nor in asthmatics below 1 mg/m.
Our study substantiates an additional function for intragenic DNA methylation and provides a novel mechanism for the positive regulation of ASE inclusion in pre-mRNA splicing.
Taken together, these analyses substantiated an important function of prolonged RelA activity in crosstalk-amplification of TLR4-induced late expressions of NF-κB target genes, particularly those encode pro-inflammatory chemokines and cytokines.
