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To the Editor: In their Editorial, Yudkin, Richter and Gale argue that 'Hyperglycaemia is a substantially weaker risk factor for CVD than cholesterol or blood pressure, and glucose-lowering interventions are correspondingly less effective' [ 1].
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This heterogeneity was mainly due to the studies by Cotterchio and colleagues from Canada 44 and Brenner and colleagues from Germany, 49 which showed substantially weaker and stronger risk reductions, respectively, than the remaining studies.
A much stronger effect is predicted for the intron 23 SNP rs4821480; with the protective alleles of rs4821480, an alternate donor site has equal predicted strength as the standard site for the start of exon 24, whereas with the risk allele the alternate motif is substantially weaker.
Other relationships such as the relation between serum oestrogen levels and breast cancer risk [ 4, 5] or breast density [ 6] are undoubtedly real, but they are substantially weaker and clearly only explain part of the relationship.
Only about 8percentt reported "substantially weaker demand" for such projects, the survey said.
The result isn't just fewer miraculous inventions, but substantially weaker growth.
The aliphatic amines are stronger bases than ammonia, and the aromatic ones are substantially weaker.
The material, reinforced carbon-carbon taken from the shuttle Discovery, is substantially weaker and less flexible than fiberglass.
But Maryland's law, according to longtime structured settlement expert Craig Ulman, is "substantially weaker" than in most states.
Revenue from its wireless chip unit fell 8percentto to $658 million, partly because of "substantially weaker demand" for wireless baseband chips.
"The claims data was substantially weaker than expected.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com