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The study protocol predefined a substantially unexpected finding which is not in accordance with the study hypothesis as a stopping criterion.
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Unexpected cholestasis substantially contributes to drug failure in clinical trials.
Because inhibitors and activators of K2P2.1 (TREK-1) are desirable for both physiological studies and as leads for therapeutic applications, this unexpected benefit substantially expands the potential of this assay to identify K2P modulators from diverse chemical libraries.
Interestingly, reduction in miR-133a using an antagomir had an indirect effect on the other myomirs, such that miR-133b (expected due to sequence similarity) and miR-206 (unexpected) were substantially reduced.
The symptoms identified for common cancers in this age group are not unexpected, but some substantially alter the prior probability of a cancer diagnosis.
Well, this is unexpected.
The auditory P3a is a large positive deflection elicited by unexpected, novel sounds which substantially differ from other sounds, for example slam of the door or human cough.
38, 53, 54 Unfortunately, the pharmacokinetic profile of LY2457546 in AML patients showed unexpected variability, and differed substantially from the preclinical pharmacokinetic data.
The fact that styrene concentrations were substantially higher in the children is unexpected, particularly because styrene is one of several VOCs known to be elevated in smokers' blood (Ashley et al. 1996; Churchill et al. 2001; Wallace et al. 1987).
Importantly, this differential is substantially larger when the job loss was unexpected.
Yet, even in such environments, by including an unexpected bonus, the employer can substantially curb worker misbehavior.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com