Several genes showed large increases in expression between the control and low concentration, with substantially smaller increases, or decreases, relative to control, at the high concentration.
Although the only statistically significant effect involves the 98% increased mortality risk associated with being classified as a dual user on both criteria, a marginally insignificant but substantially smaller increased mortality risk (45%) was associated with dual use based only on outpatient services.
In the revised Figure 5, panels B and C (same as Figure 5 C and D in the original manuscript) show substantially smaller activity increases for the three data points at higher salt concentration than in the mid-range of the curves.
Such experiments revealed that the increase in absorbance evoked in areas 3b/1 by a stimulus having both 25 and 200 Hz components was substantially smaller than the increase in absorbance evoked by "pure" 25 Hz stimulation of the same skin site.
Interestingly, ACPA-negative patients receiving placebo prednisolone or methotrexate monotherapy had substantially smaller EuroQol improvements (maximal increase of 0.04 and 0.08 units, respectively) when compared to ACPA-positive patients (maximal increase of 0.13 and 0.12 units, respectively).
While the scintillation level increase was substantially smaller for the BKK station compared to the others, it is still noticeable.
However, this increase was substantially smaller for the participants in the blocked training groups than those in the random-order training groups, simply because participants trained with the blocked method performed exceptionally well from the start.
Interestingly, C. briggsae daf-2 mutants show enhanced resistance towards S. aureus (p<0.02, Table S4) and P. aeruginosa (p<0.0001, Table S4), but the magnitude of the increase is substantially smaller than that for C. elegans daf-2 mutants (Figures 5d and 5e).
For the crystallization temperatures studied, the Avrami parameter K increased substantially for small increases in undercooling or small decreases in melt temperature and residence time.
Throughout this period, isolations of meticillin-sensitive S aureus did not decline substantially; observed small increases in sensitive S. aureus from some sample types suggestive of invasive infection may reflect nationally reported trends.
