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In intrathecal drug delivery or ITDD, medication is delivered directly into the CSF in the intrathecal space; therefore, a substantially smaller dose of medication is required as compared to the oral or intravenous route.
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Neonatal exposure to the lower dose of DZN elicited significant increases in cerebellum AC activity that were selective for males, but the higher dose instead produced small but significant decrements; the magnitude of the effects was substantially smaller than that seen in the liver at the same age (PND100).
This is substantially smaller than the conventional safety margin of 5 or 10 mm, respectively, and might allow for an additional dose escalation especially in the upper lung zone.
But since 2000, Vestre Svartisen has become "substantially smaller".
Many reckon the industry needs to become substantially smaller.
And its promotional budget will be substantially smaller too.
Sunday's cycling crowd was substantially smaller, just 170 riders.
The likelihood of accidents goes down very substantially and therefore the size of the tunnel becomes substantially smaller".
Something like Persil small & mighty laundry detergent gives great cleaning power in a much smaller dose.
It turned out to be a runt substantially smaller than the moon.
Cambridge's race gap for medical applicants is substantially smaller than that of its rival, Oxford University.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com