However, with the Soviet troops around Moscow now being reinforced by East Siberian divisions, Germany's offensive substantially slowed with the onset of the Russian winter in November and December 1941.
Application of the two novel compounds GSK-7975A GSK-5503A503A at 10 μM concentrations also resulted in complete Orai1 current inhibition, but at a substantially slower rate with a t1/2 in the range 75 100 s (Fig. 2A and E).
An important observation is that the forward rate of conformational closing (k2, Scheme 1) for mismatched dNTP incorporation is comparable with that for correct dNTP incorporation (though with significant increase in Kd), while the maximum rate of nucleotide incorporation (kpol) is substantially slower (also with significant increase in Kd,app) (Table 2).
FEM patients performed substantially slower than HCs with a large (r = .57) and medium (r = .40) effect size, respectively.
In a recent study of participants of the Memory and Aging Project — a continuing examination of 1,200 older people involving extensive lifestyle questionnaires, annual cognitive testing and brain autopsy at death — Dr. Wilson and his colleagues found that more frequent cognitive activity late in life was associated with substantially slower cognitive decline.
The second phase of the 500 nm absorbance decay occurs with a substantially slower time constant of 0.5 s, returning the remaining 20% of initial absorbance change.
The acclimatisation of most measures to altitude was substantially slower in Australians than Bolivians, with only Bolivians reaching near sea-level baseline high-intensity running by the end of the camp.
An early report from Cambodia used the median parasite clearance time (defined as the time to parasite-negative blood smears post-initiation of treatment), which was found to be substantially slower in Pailin, western Cambodia, compared with Wang Pha, Thailand (84 hours versus 48 hours, respectively).
Knocking down of MYC using shMYC in TC71 and MHH-ES Ewing sarcoma cell lines resulted in a substantially slower proliferation rate and tumorigenicity when compared with control cells (Fig. 4B and C and Supplementary Figs S7 and S8).
The kinetics of NAD+ reduction with malate or 2HG were substantially slower and thus not quantified.
