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It is very unlikely better results can be achieved with new drugs, a clinically more relevant goal would be a regimen of comparable efficacy to standard treatment but of substantially shorter duration.
However, in the Canadian study the mean time from the start of fluoroquinolone exposure to the diagnosis of RD was 4.8 days, so the substantially shorter duration of use of fluoroquinolones in the present study does not seem likely to explain the difference in the findings of the two studies.
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The placebo+MTX population included 818 patients (1107 patient-years) with a substantially shorter mean duration of follow-up (>50% withdrew from placebo follow-up by 1 year and 93% by 3 years).
Key advantages of using IVUS-based surrogate end points versus clinical outcome include smaller patient numbers and substantially shorter trial durations; this reduces costs and may expedite the development and testing of new drugs.
Interesting, this study also shows that patients with basal-like tumors do not have substantially shorter survival durations than patients with luminal-like tumors, suggesting that basal-like tumors respond well to the adjuvant adriamycin and cyclophosphamide therapies employed during their treatment.
The TST reactor proportion for persons with >3 weeks of exposure in the recruit-training platoon was substantially lower than shorter duration of exposure in the rehabilitation and separation units (RR 0.19, 95% CI 0.05 0.66, p = 0.0032).
The replicated shorter runs gave similar results so these were used because their duration was substantially shorter.
Consequently, a shorter duration model (1996 1998), with substantially reduced collinearity, was explored.
Nonetheless, it is important to note that the median follow-up time for patients diagnosed in 2006 2008 is substantially shorter and future research may observe improvements after longer durations of follow-up of this cohort.
In an oocyte donor population, other additional benefits may help to substantially decrease the treatment burden of the patient, including a shorter duration of the luteal phase (4 6 days), a reduced ovarian volume [ 18], diminished abdominal distension, and avoidance of estradiol monitoring during stimulation [ 24].
Additionally, the duration of type 2 diabetes for patients in our RCT (all recently diagnosed) was likely substantially shorter than that of the Greenville and SOS studies, which may correlate with improved diabetes remission outcomes for our trial patients.
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