As described in detail below, this pattern has been reported and substantially replicated in the context of two human phenotypes: sexual orientation and schizophrenia.
The DRL target time was increased substantially to replicate the contingencies of Bull et al. [ 22], who did not find support for impulsivity in SHR.
Repression of the GAL4 promoter by switching to glucose-based medium drove rapid adaptation [ 82] which varied substantially between replicated experiments [ 83, 84] and did not necessarily involve genetic changes [ 85].
Firstly, we corrected a mistake while converting the GEUVADIS dataset genotype information; in combination with the new approach to detect more than one epistatic interaction, this resulted in substantially more replicated examples of both v-eQTL and epistasis in the GEUVADIS cohort.
There is a general consensus that the lamivudine resistant single mutants in the YMDD motif (M550V/I) replicate substantially more slowly than the wild type.
Furthermore, when the number of families included in the dataset was low, the estimates also varied substantially from replicate to replicate.
In agreement with these observations, we observed that the respective AUG KO mutant viruses replicate to substantially lower levels in murine macrophages and mosquito cells cultured in vitro.
At later stages of the disease, when the CJD agent had replicated substantially in brain, even higher levels of agent reappeared in the blood.
However, between-replicate survival varied threefold (28 76%, mean = 46%), while genotyping revealed that the number of dams (16 23, NParents: 44 54), relative allelic richness (0.56 0.72), and observed heterozygosity (0.66 0.72) all varied substantially between replicates.
Furthermore, record systems in each of the 20 Irish maternity hospitals vary substantially and thus it may be difficult to replicate exactly the protocol implemented here.
